on behalf of the American College of Veterinary Internal Medicine. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. These relevant data are important for future studies evaluating potential efficacy of the medication for treating chronic pain states in cats. As prepared, the transdermal route is an inappropriate choice for drug administration. ANIMALS 20 osteoarthritic cats ( 10 years old). DESIGN Blinded, placebo-controlled, randomized crossover-design study. Some adverse side effects of gabapentin include lethargy, diarrhea, and anxiety. Abstract OBJECTIVE Toevaluate effects of gabapentin on activity levels and owner-perceived mobility impairment and quality of life (QOL) in osteoarthritic geriatric cats. Different doses of gabapentin can be prescribed depending on the pet’s needs. Repeated oral dosing of gabapentin did not alter the drug's pharmacokinetics, making dose adjustments unnecessary with long-term treatment. Gabapentin is an off-label anticonvulsant medicine that can be prescribed to cats to control and treat seizures, help with pain, and assist with anxiety treatment. Bioavailability after a single oral dose was 94.77% (82.46-122.83). The oral terminal half-life was 3.63 hours (2.96-4.77), and 3.72 hours (3.12-4.51) for single and repeated dosing. Compartmental analysis was used to generate gabapentin time-concentration models.Īfter IV administration CL (median (range)) and terminal half-life were 160.67 mL/kg*hr (119.63-199.11) and 3.78 hours (3.12-4.47), respectively. Plasma concentrations were determined using Ultra Performance Liquid Chromatography-Mass Spectrometry. Background: Gabapentin is the most commonly prescribed medication for the treatment of chronic musculoskeletal pain in cats. Serial blood samples were collected up to 48 hours. Gabapentin was administered as an IV bolus (5 mg/kg), orally (10 mg/kg) as a single dose or twice daily for 2 weeks, or as a transdermal gel (10 mg/kg) in serial order. To evaluate the pharmacokinetics of clinically relevant dosing regimens of gabapentin in cats.Ĭats were enrolled in a serial order, non-randomized pharmacokinetic study. Despite this common and chronic usage, clinically relevant pharmacokinetic data is lacking. The dosage for Gabapentin varies depending on the condition being treated. Your cat might also experience incoordination and diarrhea. ![]() Mild sedation in cats is the main potential side effect of the drug. Gabapentin is the most commonly prescribed medication for the treatment of chronic musculoskeletal pain in cats. Gabapentin is an anticonvulsant and analgesic drug used by vets to treat chronic pain, seizures, and anxiety in cats.
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